Tag Archives: lung cancer

Effects and Mechanisms Of PSK & PSP Against Cancers

Found this recently in a French scientific reference site ( cat.inist.fr )

Polysaccharide-K (polysaccharide-Kureha; PSK), also known as krestin, is a unique protein-bound polysaccharide, which has been used as a chemoimmunotherapy agent in the treatment of cancer in Asia for over 30 years. PSK and Polysaccharopeptide (PSP) are both protein-bound polysaccharides which are derived from the CM-101 and COV-1 strains of the fungus Coriolus versicolor by Japanese and Chinese researchers, respectively. Both polysaccharide preparations have documented anticancer activity in vitro, in vivo and in human clinical trials, though PSK has been researched longer and has therefore undergone more thorough laboratory, animal and clinical testing. Several randomized clinical trials have demonstrated that PSK has great potential as an adjuvant cancer therapy agent, with positive results seen in the adjuvant treatment of gastric, esophageal, colorectal, breast and lung cancers.

These studies have suggested the efficacy of PSK as an immunotherapy or biological response modifier (BRM). BRMs potentially have the ability to improve the host versus tumor response, thereby increasing the ability of the host to defend itself from tumor progression. The mechanisms of biological response modification by PSK have yet to be clearly and completely elucidated. Some studies suggest that PSK may act to increase leukocyte activation and response through up-regulation of key cytokines. Indeed, natural killer (NK) and lymphocyte-activated killer (LAK) cell activation has been demonstrated in vivo and in vitro, and recent genetic studies reveal increased expression of key immune cytokines in response to treatment with PSK. An antimetastatic action of PSK has also been demonstrated and is perhaps attributed to its potential to inhibit metalloproteinases and other enzymes involved in metastatic activity. PSK has also been shown to cause differentiation of leukemic cells in vitro, and this effect has been attributed to induction of differentiation cytokines.

PSK has further been shown to have antioxidant capacity which may allow it to play a role as a normal tissue chemo- and radio- protector when used in combination with adjuvant or definitive chemotherapy and/or radiotherapy in the treatment of cancer, while it may also enable it to defend the host from oxidative stress. Interestingly, studies have also shown that PSK may actually inhibit carcinogenesis by inhibiting the action of various carcinogens on vulnerable cell lines. This action of PSK may play a role in preventing second primary tumors when an inducing agent, such as tobacco or asbestos, is suspected and may also prevent second malignancies due to the carcinogenic effects of radiotherapy and cytotoxic chemotherapy. Another very important aspect of chemoimmunotherapy, in general, is that it may be used on debilitated patients such as those with AIDS and the elderly who might otherwise be denied potentially helpful adjuvant cytotoxic chemotherapy. Further determination of the mechanisms of these anti-cancer, immunostimulating and biological response modifying effects of PSK as well as of other protein-bound polysaccharides is certainly warranted. Indeed, with modem cellular and molecular biology techniques, a better understanding of the specific molecular effects of PSK on tumor cells as well as leukocytes may be determined.


Source: International Institute of Anticancer Research, Attiki, GRECE  (1980) (Revue) 2002, vol. 22, no3, pp. 1737-1754 (174 ref.)

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Coriolus & Lung Cancer Patient Video

Here is a youTube video of a Chinese lady who had lung cancer and her experience with Coriolus.

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PSP Coriolus Extract – How It Works (Mechanism Of Action) – MD Anderson, Texas

The multiple and complex mechanisms of action of Coriolus Versicolor PSP have been demonstrated through in vitro and animal studies. Coriolus PSP has suppressed the growth of human cancer cell lines in mice (sarcoma 180, lung adenocarcinoma and Lewis lung cancer).

It has also inhibited incorporation of two structural units of DNA (uridine and thymidine) in Ehrlich ascites tumor cells, inhibited the growth of P388 leukemia cells, and demonstrated anti-proliferative activity against cell lines of human gastric cancer, lung cancer, lymphoma, and mononuclear leukemia.

Coriolus PSP has reversed tumor-induced immunodeficiencies in sarcoma-bearing mice by increasing immunoglobulin G and C3 complement levels9. It has also been associated with increases in white blood cell count, serum IgG, CD4, CD8, B-lymphocytes, and neutrophils, along with a higher survival rate of tumor bearing mice3. Many of these effects have been attributed to PSP being a strong scavenger of superoxide and hydroxyl radicals. Coriolus Versicolor PSP has also been found to restrict the cell cycle of HL-60 leukemic cells through apoptosis.
These and other immune effects of PSK and PSP are described in reviews by Fisher and Yang, Ooi and Liu and Chu, Ho and Chow.

Source: (mdanderson.org)

See Also:

PSK PSP – Different Extractions of Coriolus Versicolor

Best Places to Buy Coriolus PSP

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Cancer Alternate Treatments – Lung Cancer

Testimony about treatments and alternate therapy using Coriolus Versicolor abound. Here is one such relating to lung cancer

In private practice for 15 years, Dr. Bailey has taught courses in nutrition and pharmacognosy at the National College of Naturopathic Medicine in Portland. He has been using the Coriolus versicolor polysaccharide extract for three years to relieve such illnesses as hepatitis B and C, AIDS, herpes genitalis, cancer, general immune suppression, and post-surgical recovery. Usually Dr. Bailey doesn’t administer the Coriolus polysaccharides as a single treatment agent; rather, it becomes part of his fairly comprehensive nutritional protocol.

“Of course, some cancer patients take Coriolus versicolor even while they engage in radiation treatment or chemotherapy” Dr. Bailey advises. “Or, the patients don’t submit to chemotherapy or radiotherapy at all but rely, instead, exclusively on nutritional therapies with the mushroom as a main treatment ingredient.

For example, one of my patients, a 34 year-old woman working in the health field consulted me with a cancer spreading at two sites in her lungs. Orthodox treatment had been tried but no longer was effective. She embarked on nutritional therapies and completed six months of taking Coriolus versicolor.

Radiological examination then showed that all of her lung tumors had disappeared. Seeing her current progress, orthodox medicine probably would declare this patient to be cured.”

(Extract from “ the Medicinal Mushroom – womenshealth-naturalsolutions.com)

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Coriolus – The Cancer Fighter

The more research that we do about the Coriolus Versicolor mushroom, the more staggered we become about the wide ranging information about this ‘little known’ cancer fighter. From colon cancer, lung cancer, HPV, stomach cancer…the list is endless. The immune system boosting properties of the extract are simply astonishing.

Here is another article from pskmushroom.info about the cancer fighter

Read article – Click Here

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