Archive for the Types Of Extract Category

Mushroom Glucans (PSP & PSK) in Cancer Treatments

Another narrative on the positive effects of Coriolus extracts over other mushrooms. Paragraph is highlighted…
Immunoceuticals can be considered as substances having immunotherapeutic efficacy when taken orally. More than 50 mushroom species have yielded potential immunoceuticals that exhibit anticancer activity in vitro or in animal models and of these, six have been investigated in human cancers. All are non-toxic and very well tolerated. Lentinan and schizophyllan have little oral activity. Active Hexose Correlated Compound (AHCC) is poorly defined but has shown early clinical promise. Maitake D-Fraction has limited proof of clinical efficacy to date, but controlled research is underway.

Two proteoglycans from Coriolus versicolor – PSK (Polysaccharide-K) and PSP (Polysaccharide-Peptide – have demonstrated the most promise. In Japanese trials since 1970, PSK significantly extended survival at five years or beyond in cancers of the stomach, colon-rectum, esophagus, nasopharynx, and lung (non-small cell types), and in a HLA B40-positive breast cancer subset. PSP was subjected to Phase II and Phase III trials in China. In double-blind trials, PSP significantly extended five-year survival in esophageal cancer. PSP significantly improved quality of life, provided substantial pain relief, and enhanced immune status in 70-97 percent of patients with cancers of the stomach, esophagus, lung, ovary, and cervix. PSK and PSP boosted immune cell production, ameliorated chemotherapy symptoms, and enhanced tumor infiltration by dendritic and cytotoxic T-cells. Their extremely high tolerability, proven benefits to survival and quality of life, and compatibility with chemotherapy and radiation therapy makes them well suited for cancer management regimens.
Altern Med Rev 2000 Feb;5(1):4-27
Publication Types: Review, tutorial
PMID: 10696116, UI: 20161032

Sorce: x5power.com

inForce Platinum | A Way To Save $92

If you are looking to buy 100% PSP, the best buy is the exclusive product containing Dr Yang (who invented the process) extraction PSP by inLife LLC. Its called inforce immune builder platinum. Normally $89.95 a bottle, you can buy at wholesale rates for a short period of time. This article comes from www.myinlife.co.uk

For a limited period you can become a distributor of inLife products for FREE, allowing you to buy inForce and inForce Platinum at wholesale discounted prices.

If you purchase 10 bottles of inForce Platinum as a distributor you would pay $735.54, a $92 saving on the same purchase as a retail customer.

To join just follow the ‘JOIN‘ page above. Select your country and on the second page, scroll to the bottom to find the FREE distributor option.

Once enrolled, go to your back office shop to purchase product at wholesale.

Coriolus PSP extracted under the process patented by Dr Yang is the same as that used in many of the medical studies published by hospitals and universities around the world. See Medical Studies

PSP, Polysaccahride Peptide, is an ethanol extraction from the mycelium stage of the Coriolus Versicolor mushroom.

Coriolus PSP - inForce Platinum

PSP & Prostate Cancer

For all articles regarding Prostate Cancer treatments and studies and Coriolus Versicolor  – See here

Prostate Cancer & PSP

Recent evidence suggested that prostate cancer stem/progenitor cells (CSC) are responsible for cancer initiation as well as disease progression. Unfortunately, conventional therapies are only effective in targeting the more differentiated cancer cells and spare the CSCs. Here, we report that PSP, an active component extracted from the mushroom Turkey tail (also known as Coriolus versicolor), is effective in targeting prostate CSCs. We found that treatment of the prostate cancer cell line PC-3 with PSP led to the down-regulation of CSC markers (CD133 and CD44) in a time and dose-dependent manner. Meanwhile, PSP treatment not only suppressed the ability of PC-3 cells to form prostaspheres under non-adherent culture conditions, but also inhibited their tumorigenicity in vivo, further proving that PSP can suppress prostate CSC properties. To investigate if the anti-CSC effect of PSP may lead to prostate cancer chemoprevention, transgenic mice (TgMAP) that spontaneously develop prostate tumors were orally fed with PSP for 20 weeks. Whereas 100% of the mice that fed with water only developed prostate tumors at the end of experiment, no tumors could be found in any of the mice fed with PSP, suggesting that PSP treatment can completely inhibit prostate tumor formation. Our results not only demonstrated the intriguing anti-CSC effect of PSP, but also revealed, for the first time, the surprising chemopreventive property of oral PSP consumption against prostate cancer.

Anti Tumor Effects Of PSP ( Coriolus Versicolor)

Following recent articles on PSP, here is another regarding the anti-tumor effects. Dr Yangs extraction PSP is sold under patented licence by inLife LLC as inForce Platinum. (See Shop) or go to inLife LLC website.

Anti Tumour Effect Of PSP

PSP, the protein-bound polysaccharide, extracted from a strain of Coriolus versicolor (Cov-1) by Professor Qing-yao Yang, has been proved to be effective against tumor both in animal experiments and in clinical patients. Previous results suggested that the antitumor effects of PsP were related to the potentiation of immunological responses, especially T-cell mediated immune responses of tumorbearing hosts. Since T-lymphocytes play an important role in immune response and T-cell deficiency existed in many diseases, the most noticeable one at present time is the acquired immune deficient syndrome (AIDS) which leads to the failure of T-cell functions and death. Until now there is not any effective drug in curing this disease.

It is of great interest to investigate if PSP can potentiate T-cell functions and restore the immune deficient conditions in tumor, AIDS and other viral infections. In this paper both in vivo and in vitro experiments were used to study PSP on:

1) immune organ weights,

2) antibody informations,

3) serum complement contents,

4) T lymphocyte proliferations,

5) interleukin-2 production,

6) delayed type hypersensitivity reaction,

7) phagocytic ability of reticulo-endothelial system and

Protection of liver injuries from CCl4 intoxication.

Source (mushroomstudies.com)

 

PSP – “A New Form Of Biological Response Modifier”

Coriolus Versicolor PSP is a biological response modifier. here is more research on PSP

Pharmacodynamic studies prove that PSP has a very obvious effect of strengthening health and energy to eliminate substances and is a new type of BRM (Biological response Modifier)

  1. PSP can enhance the immune function of a normal body.
    • Promote the expression of IL-6 gene of peripheral blood lymphocytes (PBL) in humans and hence induce the production of interlukin 6 (IL-6), and also activate white blood cells to increase the production of interferon alpha and game by 2 to 4 times.
    • Greatly increase the phagocytic index and raise HC50, IgG and PFC values in mice; accelerate PBL from G1 to S period and promote the proliferation of PBL.
    • Promote the proliferation of T-lymphoctes and pre-T cells in the thymus and spleen.
  1. PSP can antagonize tumour-induced immuno-suppression in animals
    • Arrest the atrophy of thymus in sarcoma bearing mice.
    • Antagonize the swelling of liver dur to Ehrlich ascites carcinoma.
    • Counteract the inhibition effect on antibody caused by sarcoma in mice.
    • Raise the value of serum complement C3 in sarcoma bearing mice.
  1. PSP can antagonize immuno-suppression caused by chemotherapeutic drugs.
    • Obviously antagonize the lowering action of white blood cells caused by cyclophosphamide and shorten the recovery time of WBC.
    • Obviously counteract the inhibitory action of cyclophosphamide on interleukin-2 (IL-2) and NK cells.
    • Restore the delayed type hypersensitivity (DTH) reaction inhibited by cyclophosphamide.
  1. PSP can inhibit the growth of cancer cells in men and animals.
    • PSP (50mg/kg, ip or po) can inhibit the growth of sarcoma 180 in mice. The inhibition rates are 46-68%.
    • A test using radioactive precursors shows that PSP (100microgram/ml) can inhibit the synthesis of nucleic acid of ehrlich ascites carcinoma. The inhibition rates of RNA and DNA are 51% and 45% respectively.
    • PSP can inhibit the growth of P388 leukemia cells, myeloma cells, hepatoma, Lewis lung cancer in mice. It can also inhibit the growth of human liver cancer, colon cancer, nasopharyngeal carcinoma, stomach cancer, human lung adenocarcinoma, monocytic leukemia and human skin histiocytic lymphoma. It can also cause the swelling of cancer cells and chromosome aggregation
    • That antilymphatic serum (ALS) can counteract the inhibitory effect of PSP on sarcoma provides counter-evidence that anti-tumour activity of PSP is related to the increase of T-lymphocytes.
  1. Other effects of PSP.
    • Obviously improve the appetite of mice being administered with cyclophosphamide.
    • Obviously decrease the painful reaction of animal caused by hot plate, acetic acid and electric stimulation.
    • inhibit the central nervous system and decrease the spontaneous activity of mice.
    • In terms of the survival time of mice in oxygen-lacking conditions, PSP test group has a much higher ability of anoxia tolerance.

(Source: http://psp-research.com)

Buy 100% PSP (Dr Yang extraction) inForce Platinum or go to shop above.

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