Archive for the Colorectal Cancer Category

Effects and Mechanisms Of PSK & PSP Against Cancers

Found this recently in a French scientific reference site ( cat.inist.fr )

Polysaccharide-K (polysaccharide-Kureha; PSK), also known as krestin, is a unique protein-bound polysaccharide, which has been used as a chemoimmunotherapy agent in the treatment of cancer in Asia for over 30 years. PSK and Polysaccharopeptide (PSP) are both protein-bound polysaccharides which are derived from the CM-101 and COV-1 strains of the fungus Coriolus versicolor by Japanese and Chinese researchers, respectively. Both polysaccharide preparations have documented anticancer activity in vitro, in vivo and in human clinical trials, though PSK has been researched longer and has therefore undergone more thorough laboratory, animal and clinical testing. Several randomized clinical trials have demonstrated that PSK has great potential as an adjuvant cancer therapy agent, with positive results seen in the adjuvant treatment of gastric, esophageal, colorectal, breast and lung cancers.

These studies have suggested the efficacy of PSK as an immunotherapy or biological response modifier (BRM). BRMs potentially have the ability to improve the host versus tumor response, thereby increasing the ability of the host to defend itself from tumor progression. The mechanisms of biological response modification by PSK have yet to be clearly and completely elucidated. Some studies suggest that PSK may act to increase leukocyte activation and response through up-regulation of key cytokines. Indeed, natural killer (NK) and lymphocyte-activated killer (LAK) cell activation has been demonstrated in vivo and in vitro, and recent genetic studies reveal increased expression of key immune cytokines in response to treatment with PSK. An antimetastatic action of PSK has also been demonstrated and is perhaps attributed to its potential to inhibit metalloproteinases and other enzymes involved in metastatic activity. PSK has also been shown to cause differentiation of leukemic cells in vitro, and this effect has been attributed to induction of differentiation cytokines.

PSK has further been shown to have antioxidant capacity which may allow it to play a role as a normal tissue chemo- and radio- protector when used in combination with adjuvant or definitive chemotherapy and/or radiotherapy in the treatment of cancer, while it may also enable it to defend the host from oxidative stress. Interestingly, studies have also shown that PSK may actually inhibit carcinogenesis by inhibiting the action of various carcinogens on vulnerable cell lines. This action of PSK may play a role in preventing second primary tumors when an inducing agent, such as tobacco or asbestos, is suspected and may also prevent second malignancies due to the carcinogenic effects of radiotherapy and cytotoxic chemotherapy. Another very important aspect of chemoimmunotherapy, in general, is that it may be used on debilitated patients such as those with AIDS and the elderly who might otherwise be denied potentially helpful adjuvant cytotoxic chemotherapy. Further determination of the mechanisms of these anti-cancer, immunostimulating and biological response modifying effects of PSK as well as of other protein-bound polysaccharides is certainly warranted. Indeed, with modem cellular and molecular biology techniques, a better understanding of the specific molecular effects of PSK on tumor cells as well as leukocytes may be determined.

 

Source: International Institute of Anticancer Research, Attiki, GRECE  (1980) (Revue) 2002, vol. 22, no3, pp. 1737-1754 (174 ref.)

Best Places To Buy

There are various different forms of Coriolus Versicolor on the market to buy. These range from low concentration to types of PSK & PSP with varying strengths and quality and extraction processes.

Here are some examples and what they provide:

PSK/PSP Dietary Supplement

As you will have read from the PSK, PSP Extraction processes page, extraction from the mycelium stem offers the most potency for PSP & PSK.

inForce by inLife LLC

5-star

Coriolus versicolor Immune System Builder uses mycelium  extraction.

NEW – inLife LLC offers a dietary supplement called inForce that uses the mycelium stem based extraction process for its immune system builder. 60 capsules x 450Mg. Contains a PSK/PSP mix.

Note:

Of all products on the market today, we recommend you to use inLife inForce. The reasons for this are several.

1. It is manufactured in the USA and has the GMP seal ( Good manufactiring Practices) so you can be assured it has been independently tested and is exactly what it claims to be.

2. Dr Yang, the inventor of the PSP mycelium extraction process and holder of the patent on the same sits on the Medical Advisory Board of inLife LLC and has given them exclusive rights to market PSP under his patent in the countries where they operate. ( USA, Canada, UK, Ireland & Spain)

3. inLIfe has a A- rating with The Better Business Bureau (www.bbb.org) and prides itself on its customer service.

4. As beacon holders to bring awareness to as many people as possible of the benfits of taking Coriolus versicolor, inLife should be supported. Their up coming infomercial hosted by Cristina Ferrare will hopefully catapult Coriolus into the mainstream.

Price: $34.95

Click to go to inLife Page

(Note: inLife inForce is available to purchase in USA, Canada, UK, Ireland & Spain)

Coriolus by Mushroom Science

mscoriolus2Mushroom Science makes a fruit body extract of PSK in 90x 600Mg capsule form

Price: $54.86

Click to Go To Site

HerbsPro

HerbsPro offers a range of Coriolus Versicolor products sometimes at discounted prices. The details on the products are not always clear so we are unable to determine the quality of the PSK or PSP of some of the products listed on the site but it can be useful to cross check other listed product on this page for special offers.

Go To HerbsPro Wesite – Click Here

Anti-Tumour | Liver Tumours & Coriolus Versicolor

Here is an interesting testimonial from You Tube mentioning effects of inForce Coriolus Versicolor on someone with tumours on their liver.

Coriolus Versicolor – The Miracle Mushroom

This extract taken from quantumhealing.co.za details various trials and treatments of Coriolus Versicolor.

It shrank his liver tumor by 90%––after his doctor gave up on him.

A man describes his oncologist as “the most negative man I ever met.” The doctor treated Mr. G. for liver cancer for six years, then gave him up as untreatable. “After the chemo failed, he threw up his hands, shrugged his shoulders, wished me good luck, and said there was nothing else he could do,” according to Mr. G. “And surgery couldn’t be performed either, because the consulting surgeon saw that the tumor was wrapped around my vena cava blood vessel.”

Mr G. told his oncologist, “I totally reject what you are telling me. I do not accept that nothing can be done to affect the outcome of this disease.” The doctor said, “Well, I know what I’m talking about when it comes to cancer. I’m a scientist.”

Mr G. shot back, “Yes, but you’re not God!” Four years later the patient was healthy again after using the type of therapies known as CAIM (complementary/ alternative/integrative medicine), especially including capsules containing the powdered extract of a mushroom, Coriolus versicolor. Mr G. learned about the remedy on the Internet and he can tell you all about it, having downloaded nearly 400 studies.

Amazingly, Mr. G.’s liver cancer reduced to less than ten percent of its original size. His CEA (carcinoembryonic antigen) cancer marker fell more than two-thirds from 296 to 97.9.

What is Coriolus Versicolor?

Like all mushrooms, Coriolus versicolor is a fungus, one of more than a half million varieties worldwide. Many of them have been known for thousands of years to have medicinal properties. And as you may know, gourmets the world over prize both wild and commercially grown mushrooms. Some European cookbooks even call them “flowers of the fall.” Whatever you call them, certain mushrooms are a perfect food for staying trim and healthy. They have little or no fat and some species, like Coriolusversicolor, boast valuable therapeutic and nutritional benefits. But a few fungi are poisonous and we do not recommend that nonexperts attempt to harvest their own. Coriolus versicolor goes by a number of botanical names, including Trametes versicolor and Boletus versicolor.

“Versicolor” refers to the mushroom’s various colors. In North America, the common name is “turkey tail,” while in Japan it is called by a name meaning “mushroom by the river bank” and in China its name indicates it’s a cloud fungus that grows best in the rain.

Over 400 clinical studies have shown that a purified extract derived from the mushroom Coriolus versicolor offers strong benefits for the immune system. Clinical studies indicate the extract’s ingredients are especially effective against stomach, uterine, colon and lung cancer.

Anecdotal evidence and clinical experience suggest it also works well against prostate, breast, liver and colorectal  cancer. Studies of rats and mice show that this mushroom is effective against many experimental animal cancers such as sarcoma and hepatoma.

Martha I.’s lung cancers disappear

“Of course,” says Dr. Bailey, “some cancer patients take Coriolus versicolor even while they engage in radiation treatment or chemotherapy. Or the patients don’t submit to chemotherapy or radiotherapy at all but rely, instead, exclusively on nutritional therapies with the medicinal mushroom as the main treatment ingredient.

“For example, one of my patients, Martha I., a 34-year-old woman working in the health field, consulted me with a cancer spreading at two sites in her lungs. Orthodox treatment had been tried but no longer was effective. She discontinued her smoking of two cigarette packs a day and embarked on nutritional therapies.

The nutrients included Martha’s completing six months of taking Coriolus versicolor. After this halfyear, radiological examination showed that all of her lung tumors had disappeared. Seeing her current progress, orthodox medicine probably would declare this patient to be cured.”

Blood tests show how the mushroom boosts immunity

I spoke with a doctor who measures natural killer cell (NK) counts and considers them a valuable cancer

marker. Kenneth Bock, M.D., is the medical director of two holistic medical clinics, one in Rhinebeck, New York and the other in Albany. “Because it increases natural killer (NK) cell activity, I think of using Coriolus versicolor mainly when I’m confronted with a patient suffering from cancer or a viral infection,” he says. “This mushroom is one of the main medicinal compounds I use to boost a diminished blood reading which records NK activity. The mushroom’s active biological response modifier produces a marked improvement in NK cell function and number, something I monitor by blood testing. If the blood reading is low, my patient takes greater amounts of PSK capsules. And, although it’s an expensive and sophisticated assay, I repeat my NK cell testing inside of a month or two. In a number of patients, I’ve seen some nice blood test improvement.”

Dr. Bock finds that a few patients with advanced metastatic cancer see their NK counts jump from 2 or 3 to a normal 20 to 50.

Patient’s immune system recovers

“I can illustrate what I’m saying by providing a before-and-after case history plus the literature that backs my claim,” Dr. Bock states. His patient was a white, married computer consultant named Marty E., sixty years old and suffering from high blood pressure and arteriosclerosis when he was also found to have polyps on his larynx. These were removed, with radiation therapy as a follow-up. But then Marty E. was also found to have prostate cancer.

“His blood test showed diminished natural killer cell activity at the level of 6 m/u,” Dr. Bock states. “Still, Marty wanted no conventional therapy for prostate cancer. So I started him on alternative medical therapies for prostate cancer and to improve his deficient NK cell activity. Coriolus versicolor was a definite part of his treatment regimen.

“Within two months, the patient’s NK cell activity elevated to 18 m/u. And two months after that his NK cell activity increased to a normal 31 m/u. Now the man is doing well physically, and he tells me he feels great! I would say this type of response to the  PSK therapy is usual; the patient’s quality of life does improve dramatically and he or she feels asense of well-being,” according to Dr. Bock.

A naturpathic doctor named Tori Hudson told of her clinical experience using PSK for breast cancer patients during and after chemotherapy. “My impression is that patients taking Coriolus versicolor are experiencing less side effects from chemotherapy such as diminished fatigue, less nausea (but not less hair loss), and more stable white blood cell counts. I have not measured natural killer cell counts,” she states.

Animal studies confirm what patients see for themselves

Animal studies show PSK is effective against a long list of cancers including melanoma, sarcoma, mammary cancer, colon cancer and lung cancer. Studies also show it inhibits metastasis to other sites. The studies indicate PSK enhances the immune system and battles cancer cells. It’s been shown to prolong the survival time and stimulate the production of cancer antibodies in mice with cancer.

PSK is also a potent antiviral remedy that may hold new hope for HIV-AIDS. It even lowers cholesterol in animals and speeds up recovery from burns in rabbits when used in combination with the herb Astragalus membranaceus.

Can be used in combination with conventional treatments

Human patients who have decided to stick with conventional chemotherapy and radiation therapy need to know that PSK renders these toxic treatments much more effective, as shown by a number of clinical studies.

A Japanese study looked at the effectiveness of 200 phytochemicals (plant substances) when used in combination with chemotherapy and radiation. Coriolus versicolor was found to be the best of the bunch. The researchers suggest that this medicinal mushroom seems to protect the immune system from being suppressed by prolonged use of chemotherapy drugsand by the cancer itself.

Further investigations indicate a marked improvement in the survival rates of chemo and radiationpatients taking the mushroom therapy when compared with those who did not. For patients with Stage I lung cancer observed over ten years, the tumor shrinkage and survival rate was 39 percent for those taking PSK compared to only 16 percent for patients receiving the toxic therapies without the mushroom extract. That’s a huge difference––more than twice as many survived and/or improved with the help of PSK.

Those lung cancer patients with more serious Stage II cancer experienced a 22 percent tumor shrinkage and survival rate over ten years when they took Coriolus versicolor orally while being treated with chemo or radiation. Among the people who didn’t take the herbal remedy the figure was a mere five percent.

From this study of 185 lung cancer patients it appears the mushroom extract can make the toxic therapies anywhere from two to four times more effective.

A Japanese study of 262 gastric cancer patients tested the mushroom’s efficacy following surgery. During a follow-up period ranging from five to seven years, the half who received the mushroom extract survived at substantially higher rates. The researchers concluded that PSK was a useful adjunctive therapy to surgery and chemo.

A Japanese study of breast cancer patients found similar results: Those who received PSK along with chemotherapy had better outcomes than those who did not. And a study of 28 patients suffering from acute leukemia––all on chemotherapy––showed an average survival time of 21 months for those who took the mushroom extract and 12 months for those who did not.

Coriolus – The Cancer Fighter

The more research that we do about the Coriolus Versicolor mushroom, the more staggered we become about the wide ranging information about this ‘little known’ cancer fighter. From colon cancer, lung cancer, HPV, stomach cancer…the list is endless. The immune system boosting properties of the extract are simply astonishing.

Here is another article from pskmushroom.info about the cancer fighter

Read article – Click Here

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