Archive for the News Category

Anti Tumor Effects Of PSP ( Coriolus Versicolor)

Following recent articles on PSP, here is another regarding the anti-tumor effects. Dr Yangs extraction PSP is sold under patented licence by inLife LLC as inForce Platinum. (See Shop) or go to inLife LLC website.

Anti Tumour Effect Of PSP

PSP, the protein-bound polysaccharide, extracted from a strain of Coriolus versicolor (Cov-1) by Professor Qing-yao Yang, has been proved to be effective against tumor both in animal experiments and in clinical patients. Previous results suggested that the antitumor effects of PsP were related to the potentiation of immunological responses, especially T-cell mediated immune responses of tumorbearing hosts. Since T-lymphocytes play an important role in immune response and T-cell deficiency existed in many diseases, the most noticeable one at present time is the acquired immune deficient syndrome (AIDS) which leads to the failure of T-cell functions and death. Until now there is not any effective drug in curing this disease.

It is of great interest to investigate if PSP can potentiate T-cell functions and restore the immune deficient conditions in tumor, AIDS and other viral infections. In this paper both in vivo and in vitro experiments were used to study PSP on:

1) immune organ weights,

2) antibody informations,

3) serum complement contents,

4) T lymphocyte proliferations,

5) interleukin-2 production,

6) delayed type hypersensitivity reaction,

7) phagocytic ability of reticulo-endothelial system and

Protection of liver injuries from CCl4 intoxication.

Source (mushroomstudies.com)

 

Coriolus Versicolor PSP Physiological Effects

Physiological Effects of Coriolus PSP

We found this interesting article regarding physiological effects of Coriolus Versicolor PSP. Most of the references use the Dr Yang extraction PSP that can be bought in the form of inForce Platinum by inLife llc or by visiting the inForce shop. Just click the SHOP link above.

  • Promotes the proliferation of T cells and pre-T cells.
  • Increases thymus weight.
  • Increases the biological effects of radiation.
  • Possesses direct cytotoxic effects to tumor cells and inhibits tumor growth.
  • Increases the production of IL-2, IgG, C3, and interferon.
  • Raises the activities of NK cells and macrophages.
  • Maintains and raises white blood cell count.
  • Lessens the side effects of chemotherapy and radiotherapy.
  • Reduces pain in terminal patients.
  • Prevents liver injuries induced by CCl4 (carbon-tetrachloride-based drugs).

References

Yang QY, Yong SC, Yang XT.  The physio-chemical characteristics of the polysaccharide-peptide (PSP) of Coriolus versicolor (Yun Zhi).  In: Report on the polysaccharide-peptide (PSP) of Coriolus versicolor, 1987: pp1-6.  Landford.  China.

Liu WK, Ng TB, Sze SF, Tsui KW.  Activation of peritoneal macrophages by polysaccharopeptide from the mushroom Coriolus versicolor.  Immunopharmacology 1993; 26: 139-146.

Dong Y, Kwan CY, ChenZN, Yang MMP.  Antitumor effects of a refined polysaccharide peptide fraction isolated from Coriolus versicolor: in vitro and in vivo studies.  Research communication in Molecular Pathology and Pharmacology 1996, 92(2): 140-148.

Yang QY, Yan P.  Isolation of the polysaccharide components of PSP.  J. Shanghai Teach. Univ. (Natural Sciences Ed.) 1986; 4: 36.

Liu TF, Xue WC.  Clinical implication of PSP in oncology.  In: Recent Advances in Cancer, published by Cancer Research Group, CUHK, 1989: 57-62.

Li SM, Xu LZ.  A study of anti-cancer effects of PSP and PSK on human tumor cell lines in vitro.  Acta Acad. Med., Shanghai, 1987, 14: 23-24.

Zhou JX, Li XY, Shen XL.  The anti-tumor and immunomodulating activity of PSP in mice.  J. Shanghai Teach. Univ. (Natural Sciences Ed.) 1988, 3:72.

Li SY, Wang JF.  Immuno-modulating actions of PSP.  In: Recent Advances in Cancer, published by Cancer Research Group, CUHK, 1989: 45-56.

Li XY, Wang JF, Zhu PP, Ge JB, Yang SX.  Immune enhancement of polysaccharides peptides isolated from Coriolus versicolor.  Acta Pharm. Sinica 1990, 11: 542-45.

Yang MMP, Chen ZN, Kwok JSL.  The anti-tumor effect of a small polypeptide from Coriolus versicolor.  American J. Chinese Med. 1992, 20: 221-232.

Shiu WCT, Leung TWT, Tao M.  A clinical study of PSP on peripheral blood counts during chemotherapy.  Phytotherapy Res. 1992, 6: 217.

Xue WC, Liu TF.  Clinical experience in the use of PSP.  Cancer Hospital, Shanghai Medical University.

Sun ZY, et al.  The preliminary appraisal of polysaccharide peptide (PSP) in malignant and non-malignant diseases.  Shanghai Medical University.

Zhou JX, Shen XL, Shen ZM, Li XY.  Antitumor effect of polysaccharide peptide of Coriolus versicolor (PSP) and its mechanism.  Department of Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai, China.

(Source: www.naturodoc.com)

Coriolus PSP Found To Supress Prostate Tumours – QUT

Coriolus PSP (Polysaccharide Peptide), used in Asia for its medicinal benefits has been found to be 100 per cent effective in suppressing prostate tumour development in mice during early trials, new Queensland University of Technology (QUT) research shows.

The compound, polysaccharopeptide (PSP), which is extracted from the ‘turkey tail’ mushroom, was found to target prostate cancer stem cells and suppress tumour formation in mice, an article written by senior research fellow Dr Patrick Ling in the international scientific journal PLoS ONE said.

Dr Ling, from the Australian Prostate Cancer Research Centre-Queensland and Institute for Biomedical Health & Innovation (IHBI) at QUT, said the results could be an important step towards fighting a disease that kills 3000 Australian men a year.

“The findings are quite significant,” Dr Ling said.

“What we wanted to demonstrate was whether that compound could stop the development of prostate tumours in the first place.

“In the past, other inhibitors tested in research trials have been shown to be up to 70 per cent effective, but we’re seeing 100 per cent of this tumour prevented from developing with PSP.

“Importantly, we did not see any side effects from the treatment.”

Dr Ling said conventional therapies were only effective in targeting certain cancer cells, not cancer stem cells, which initiated cancer and caused the disease to progress.

During the research trial, which was done in collaboration with The University of Hong Kong and Provital Pty Ltd, transgenic mice that developed prostate tumours were fed PSP for 20 weeks.

Dr Ling said no tumours were found in any of the mice fed PSP, whereas mice not given the treatment developed prostate tumours. He said the research suggested that PSP treatment could completely inhibit prostate tumour formation.

“Our findings support that PSP may be a potent preventative agent against prostate cancer, possibly through targeting of the prostate cancer stem cell population,” he said.

He said PSP had been previously shown to possess anti-cancer properties, and ‘turkey tail’ mushrooms (known as Coriolus versicolor or Yun-zhi) had been widely used in Asia for medicinal benefits.

However, Dr Ling said it was the first time it had been demonstrated that PSP had anti-cancer stem cell effects.

Although ‘turkey tail’ mushrooms had valuable health properties, Dr Ling said it would not be possible to get the same benefit his research showed from simply eating them.

A fundraiser has been organised in September to support further tests for the therapeutic potential of PSP against prostate tumours either alone or in combination with other anti-cancer compounds.

Source: (www.news.qut.edu.au)

inForce – Coriolus PSP/PSK Immune Builder Now Available Worldwide

inForce immune builder, our No.1 choice for Coriolus versicolor products is now available worldwide. Previously, the supplement was only available to ship to a limited number of coutries outside the USA.

inLife LLC , the company who supply the product have opened up several new markets on every continent and are promoting the product in the USA using a 30 minute infomercial hosted by OWN Network TV celebrity Cristina Ferrare.

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